While all OpenType fonts will work in nearly all existing software, only some applications take full advantage of the OpenType advanced layout features. Applications such as InDesign, Illustrator, PhotoShop, QuarkXPress 7 (and higher) and Mellel offer these options.
Other applications such as QuarkXPress 6, FreeHand and Word only offer access to the first 256 glyphs of the fonts, ignoring the others. Fedra Sans Pro, for example, includes 2,540 glyphs, so in these programs you will be only able to use about 10% of the fontʼs possibilities.
See a detailed table of supported OpenType features in various applications.